We present Syft, a general-purpose framework which combines a core group of privacy-enhancing technologies that facilitate a universal set of structured transparency systems. This framework is demonstrated through the design and implementation of a novel privacy-preserving inference information flow where we pass homomorphically encrypted activation signals through a split neural network for inference. We show that splitting the model further up the computation chain significantly reduces the computation time of inference and the payload size of activation signals at the cost of model secrecy. We evaluate our proposed flow with respect to it's provision of the core structural transparency principles.