Abstract: We propose an effective denoising diffusion model for generating high-resolution images (e.g., 1024$\times$512), trained on small-size image patches (e.g., 64$\times$64). We name our algorithm Patch-DM, in which a new feature collage strategy is designed to avoid the boundary artifact when synthesizing large-size images. Feature collage systematically crops and combines partial features of the neighboring patches to predict the features of a shifted image patch, allowing the seamless generation of the entire image due to the overlap in the patch feature space. Patch-DM produces high-quality image synthesis results on our newly collected dataset of nature images (1024$\times$512), as well as on standard benchmarks of LHQ(1024$\times$ 1024), FFHQ(1024$\times$ 1024) and on other datasets with smaller sizes (256$\times$256), including LSUN-Bedroom, LSUN-Church, and FFHQ. We compare our method with previous patch-based generation methods and achieve state-of-the-art FID scores on all six datasets. Further, Patch-DM also reduces memory complexity compared to the classic diffusion models. Project page: https://patchdm.github.io.