CortiLife: A Unified Framework for Cortical Representation Learning across the Lifespan

The human cerebral cortex encodes rich neurobiological information that is essential for understanding brain development, aging, and disease. Although various cortical representation learning methods have been proposed, existing models are typically restricted to stage-specific cohorts and lack generalization across the lifespan. While recent vision-language models offer a promising direction, building a unified framework for cortical representation faces three key challenges: (1) the non-Euclidean manifold structure of cortical surfaces, (2) homogenization of individual folding patterns induced by registration, and (3) distribution shifts of cortical features across the lifespan. To address these issues, we present CortiLife, the first unified vision-language framework for lifespan-aware cortical representation learning. Specifically, CortiLife introduces a surface tokenizer that integrates icosahedron-based surface patchification with multi-level patch encoding to transform complex cortical manifolds into compact token representations. The multi-level encoding incorporates three complementary streams that capture local topology, global interactions, and patch-wise distributional patterns, effectively mitigating the challenges of homogenization and distribution shifts. Furthermore, CortiLife integrates masked self-distillation with metadata language prompting, embedding information such as age, sex, health status, and attribution type into the text encoder to better capture individual-specific cortical representations while enabling both age-aware and modality-aware modeling. Extensive experiments on downstream tasks, including two encoder-frozen tasks (age prediction and cortical parcellation) and four encoder fine-tuning tasks (brain disorder diagnosis), demonstrate that CortiLife consistently outperforms state-of-the-art baselines across different age stages and modality types, underscoring its effectiveness and generalization ability.