Post-training KV-Cache compression methods typically either sample a subset of effectual tokens or quantize the data into lower numerical bit width. However, these methods cannot exploit redundancy in the hidden dimension of the KV tenors. This paper presents a hidden dimension compression approach called Palu, a KV-Cache compression framework that utilizes low-rank projection to reduce inference-time LLM memory usage. Palu decomposes the linear layers into low-rank matrices, caches compressed intermediate states, and reconstructs the full keys and values on the fly. To improve accuracy, compression rate, and efficiency, Palu further encompasses (1) a medium-grained low-rank decomposition scheme, (2) an efficient rank search algorithm, (3) low-rank-aware quantization compatibility enhancements, and (4) an optimized GPU kernel with matrix fusion. Extensive experiments with popular LLMs show that Palu compresses KV-Cache by 50% while maintaining strong accuracy and delivering up to 1.89× speedup on the RoPE-based attention module. When combined with quantization, Palu’sinherent quantization-friendly design yields small to negligible extra accuracy degradation while saving additional memory than quantization-only methods and achieving up to 2.91× speedup for the RoPE-based attention. Moreover, it maintains comparable or even better accuracy (up to 1.19 lower perplexity) compared to quantization-only methods. These results demonstrate Palu’s superior capability to effectively address the efficiency and memory challenges of LLM inference posed by KV-Cache. Our code is publicly available at: https://github.com/shadowpa0327/Palu.